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The cause of the cleft palate in the Pierre Robin sequence is thought to be mechanical obstruction of the lateral palatine processes as they swing from a vertical to horizontal orientation during palate fusion, and not because of failure of the fusion process secondary to programmed cell death. The micrognathia and associated glossoptosis causes this obstruction, resulting in the characteristic wide horseshoe cleft palate

Melanin Inhibition: Converts eumelanin (dark pigment) to pheomelanin (light pigment), resulting in visible skin lightening and brightening

It is more likely to cause gastrointestinal side effects, including diarrhea, and may be less efficient at raising serum magnesium levels

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